Description

n-Methylaniline n-Glucuronide is a glucuronide conjugate metabolite of N-methylaniline, a compound of significant interest in toxicological and metabolic studies. This specific metabolite is crucial for researchers and industries focused on understanding xenobiotic metabolism, bioactivation pathways, and developing analytical standards. It serves as a vital reference material for laboratories in the pharmaceutical, contract research organization (CRO), and analytical chemistry sectors, where precise metabolite identification and quantification are paramount.

Application

• Metabolite Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments in mass spectrometry and HPLC.
• Toxicology Research: Essential for studying the metabolic fate and detoxification pathways of aromatic amines like N-methylaniline.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to identify and quantify Phase II conjugation products.
• Biomarker Development: Potential use in developing biomarkers of exposure for occupational or environmental monitoring related to aniline derivatives.
• Analytical Method Development: Serves as a key component in validating new LC-MS/MS or GC-MS methods for metabolite detection.
• Regulatory Submissions: Provides necessary data and reference materials for regulatory filings requiring detailed metabolite profiles.

Basic Information

Product Name	n-Methylaniline n-Glucuronide
CAS No.	121054-06-6
Molecular Formula	C13H17NO6
Molecular Weight	283.28 g/mol
Synonyms	N-Methylaniline N-Glucuronide; N-Methylaniline Glucuronide; 1-[(4-Methylphenyl)amino]-1-deoxy-β-D-glucopyranuronic acid; N-(p-Tolyl)-β-D-glucopyranuronosylamine; N-Methylaniline D-Glucuronide; Glucuronide conjugate of N-Methylaniline; N-Methylphenylglucuronide
EINECS	Contact for details

Quality Control

Our n-Methylaniline n-Glucuronide is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to reach room temperature before opening to prevent condensation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.