Description

(±)-trans-Azetidine-2,4-Dicarboxylic Acid CAS NO 121050-03-1 is a conformationally restricted analog of the excitatory neurotransmitter glutamate, serving as a potent and selective agonist for metabotropic glutamate receptors (mGluRs). This compound is a critical pharmacological research tool for studying neurological pathways and receptor subtypes involved in various CNS disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and fine chemical suppliers engaged in the development of novel neurotherapeutics and diagnostic agents.

Application

• Neuroscience Research: A key tool compound for investigating the function and pharmacology of Group I and II metabotropic glutamate receptors (mGluR1/5, mGluR2/3).
• Drug Discovery: Serves as a high-purity reference standard and building block in the synthesis of potential neuroprotective agents, analgesics, and treatments for anxiety, depression, and schizophrenia.
• Biochemical Assay Development: Used in high-throughput screening (HTS) campaigns and functional assays (e.g., calcium flux, cAMP inhibition) to identify and characterize new mGluR modulators.
• Academic Studies: Employed in university and institutional labs for fundamental research on synaptic transmission, neuronal excitability, and the role of glutamate in learning and memory.
• Chemical Intermediate: Acts as a versatile chiral synthon for the preparation of more complex, pharmacologically active molecules targeting ionotropic and metabotropic glutamate receptors.

Basic Information

Product Name	(±)-trans-Azetidine-2,4-Dicarboxylic Acid
CAS No.	121050-03-1
Molecular Formula	C6H7NO4
Molecular Weight	157.12 g/mol
Synonyms	trans-2,4-Azetidinedicarboxylic Acid; (±)-trans-Azetidine-2,4-dicarboxylic acid; (2R,4S)- and (2S,4R)-Azetidine-2,4-dicarboxylic Acid; trans-ADCA; DL-trans-Azetidine-2,4-dicarboxylic Acid; 1-Azaspiro[3.3]heptane-2,4-dicarboxylic acid (non-IUPAC); NSC 698366; Glutamate analog, trans-azetidine dicarboxylate
EINECS	Contact for details

Quality Control

Our (±)-trans-Azetidine-2,4-Dicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify the trans-isomer ratio. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring compliance with research-grade standards. Our quality commitment supports reliable and reproducible results in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Trans-isomer Ratio	≥ 95:5 (trans:cis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.