Description

Sphingofungin D is a potent, naturally occurring sphingolipid analog and a specific inhibitor of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis. This targeted mechanism of action makes it a critical research tool for studying cellular signaling, apoptosis, and lipid metabolism pathways. It is primarily utilized by researchers in the pharmaceutical, biotechnology, and academic sectors for drug discovery and biochemical research.

Application

• Biochemical Research: As a specific inhibitor of serine palmitoyltransferase (SPT) to study de novo sphingolipid synthesis and its role in cell physiology.
• Cell Biology Studies: For investigating the impact of disrupted sphingolipid metabolism on cell growth, differentiation, and programmed cell death (apoptosis).
• Drug Discovery & Target Validation: Used in high-throughput screening and mechanistic studies to identify and validate new therapeutic targets related to sphingolipid-associated diseases.
• Academic Research: A key reagent in university and institutional labs for fundamental research into lipid signaling networks and metabolic disorders.
• Pharmaceutical Development: Serves as a reference compound or lead structure in the development of novel antifungal or anticancer agents targeting sphingolipid pathways.

Basic Information

Product Name	Sphingofungin D
CAS No.	121025-47-6
Molecular Formula	C21H39NO5
Molecular Weight	385.54 g/mol
Synonyms	(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecene-1,5-diol; Sphingofungin D; LCB2 inhibitor; Serine palmitoyltransferase inhibitor; SPT inhibitor; Antibiotic FR-900848 derivative; Sphingolipid biosynthesis inhibitor.
EINECS	Contact for details

Quality Control

Our Sphingofungin D is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.