Description

Kinamycin E is a potent, structurally complex antibiotic belonging to the kinamycin family of natural products, characterized by a unique diazofluorene core. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity, particularly as a DNA-damaging agent and potential anticancer lead. It serves as a critical reference standard and building block for researchers in medicinal chemistry, pharmacology, and synthetic biology. Industries involved in advanced life science research, oncology drug discovery, and the synthesis of novel bioactive compounds are the primary users of this high-value chemical.

Application

• Pharmaceutical Research: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of novel anticancer therapeutics.
• Medicinal Chemistry: Serves as a core scaffold or lead compound for structure-activity relationship (SAR) studies and the synthesis of analogs with optimized potency and pharmacokinetic profiles.
• Biochemical Research: Employed as a tool compound to study mechanisms of DNA interaction, cleavage, and cellular apoptosis in experimental oncology.
• Academic Research: Utilized in universities and research institutes for fundamental studies on natural product biosynthesis, antibiotic mechanisms, and chemical biology.
• Standards and Metrology: Acts as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in laboratories.

Basic Information

Product Name	Kinamycin E
CAS No.	120796-26-1
Molecular Formula	C24H17NO8
Molecular Weight	447.40 g/mol
Synonyms	Kinamycin E; Antibiotic SL 1956F; 11-Deoxy-4-demethyl-11-oxokinamycin C; 2,5,7-Trihydroxy-8-methyl-3-[(1E)-1-(2-methyl-1,3-dioxolan-2-yl)prop-1-en-2-yl]-9,10-anthraquinone; 9,10-Anthracenedione, 2,5,7-trihydroxy-8-methyl-3-[(1E)-1-(2-methyl-1,3-dioxolan-2-yl)-1-propen-2-yl]-; SL 1956F
EINECS	Contact for details

Quality Control

Our Kinamycin E is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory and compliance needs in preclinical and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is both light-sensitive and hygroscopic. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to Orange Powder
Identification (HPLC)	Conforms to Reference Standard
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.