Description

Estradiol-3-Trimethylsilyl Ether-17-Heptafluorobutyrate is a high-purity, chemically modified derivative of estradiol, specifically designed for analytical and research applications. This compound is a critical reference standard and intermediate in the synthesis and quantification of steroid hormones and their metabolites. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of diagnostic kits for precise analytical work, including mass spectrometry and chromatography.

Application

• Analytical Reference Standard: Serves as a certified standard for the calibration and validation of analytical methods in hormone testing.
• Mass Spectrometry (GC-MS/LC-MS): Used as a derivatization agent or internal standard for the sensitive detection and quantification of estradiol and related steroids.
• Pharmaceutical Research: Acts as a key synthetic intermediate in the development of novel steroid-based therapeutics and prodrugs.
• Clinical Diagnostics: Employed in the manufacturing and quality control of immunoassays and diagnostic reagents for endocrine function.
• Metabolite Studies: Facilitates research into steroid metabolism pathways and the identification of metabolic byproducts.
• Forensic Toxicology: Used in confirmatory testing for anabolic steroids and other performance-enhancing drugs.

Basic Information

Product Name	Estradiol-3-Trimethylsilyl Ether-17-Heptafluorobutyrate
CAS No.	120623-45-2
Molecular Formula	C29H39F7O3Si
Molecular Weight	620.70 g/mol
Synonyms	Estradiol 3-TMS Ether 17-Heptafluorobutyrate; 17β-Estradiol 3-(trimethylsilyl) Ether 17-Heptafluorobutyrate; E2-3TMS-17HFB; Estradiol-3-TMS-17-HFB Derivative; Heptafluorobutyric Acid 17β-Estradiol 3-(trimethylsilyl) Ether Ester; 3,17β-Bis[(2,2,3,3,4,4,4-heptafluorobutanoyl)oxy]estra-1,3,5(10)-trien-3-yl Trimethylsilyl Ether (related IUPAC); Steroid Derivative for GC-MS
EINECS	Contact for details

Quality Control

Every batch of Estradiol-3-Trimethylsilyl Ether-17-Heptafluorobutyrate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with rigorous standards suitable for research and analytical use. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.