Description

Cki-7 CAS NO 120615-25-0 is a potent and selective inhibitor of the protein kinase CK1 (Casein Kinase 1), a key enzyme involved in various cellular signaling pathways. This high-purity chemical is essential for research and development in molecular biology and pharmacology, enabling precise modulation of Wnt/β-catenin and circadian rhythm pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for target validation, mechanism-of-action studies, and early-stage drug discovery programs.

Application

• Biochemical Research: A critical tool for studying the role of CK1 isoforms (δ, ε, α) in cellular processes, including signal transduction, cell cycle progression, and gene expression.
• Pharmaceutical Development: Used as a reference standard and pharmacological probe in the discovery of novel therapeutics targeting cancers, neurodegenerative diseases, and circadian rhythm disorders.
• Academic Studies: Facilitates fundamental research into the Wnt signaling pathway, which is crucial for understanding development, stem cell biology, and oncogenesis.
• Target Validation: Employed in in vitro and cell-based assays to confirm CK1 as a viable drug target for specific disease models.
• High-Throughput Screening (HTS): Serves as a control compound in screening campaigns to identify new CK1 inhibitors with improved potency or selectivity.

Basic Information

Product Name	Cki-7
CAS No.	120615-25-0
Molecular Formula	C₁₄H₁₅N₅O₂
Molecular Weight	285.30 g/mol
Synonyms	CK1-7; CKI-7; CKI 7; N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide dihydrochloride; 5-Chloro-N-(2-aminoethyl)-1-isoquinolinesulfonamide; Casein Kinase I Inhibitor CKI-7; CK1 Inhibitor VII; 8-(Aminoethylamino)-5-chloroisoquinoline-8-sulfonamide
EINECS	Contact for details

Quality Control

Every batch of Cki-7 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for research-grade biochemicals, supporting reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider keeping the product desiccated under an inert atmosphere. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.