Description

Acetaminophen Glucuronide Sodium Salt is a key metabolite of the widely used analgesic and antipyretic drug, acetaminophen (paracetamol). This high-purity reference standard is essential for accurate analytical research and quality control in pharmaceutical development. It is primarily utilized by researchers and quality assurance professionals in the pharmaceutical, biotechnology, and clinical diagnostics industries for metabolite profiling, pharmacokinetic studies, and method validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantification of acetaminophen metabolites in drug substance and drug product testing.
• Metabolite Profiling & Pharmacokinetics (PK/PD): Critical for in vitro and in vivo studies to understand drug metabolism, clearance rates, and bioavailability.
• Clinical Diagnostics & Toxicology: Used as a calibrator in LC-MS/MS and HPLC assays to monitor acetaminophen levels and its glucuronide conjugate in human plasma and urine for therapeutic drug monitoring and overdose cases.
• Biochemical Research: Employed in enzymatic studies related to UDP-glucuronosyltransferase (UGT) activity and glucuronidation pathways.
• Method Development & Validation: Essential for developing, qualifying, and validating analytical methods in compliance with ICH, FDA, and EMA guidelines.

Basic Information

Product Name	Acetaminophen Glucuronide Sodium Salt
CAS No.	120595-80-4
Molecular Formula	C15H17NNaO9
Molecular Weight	378.28 g/mol
Synonyms	Paracetamol Glucuronide Sodium Salt; APAP Glucuronide Sodium Salt; 4'-Hydroxyacetanilide Glucuronide Sodium Salt; N-Acetyl-p-aminophenyl-β-D-glucopyranosiduronic Acid Sodium Salt; 2-(Acetamidophenyl) 1-β-D-Glucopyranosiduronic Acid Sodium Salt; Acetaminophen β-D-Glucuronide Sodium; (2S,3S,4S,5R,6S)-6-(4-Acetamidophenoxy)-3,4,5-trihydroxyoxane-2-carboxylic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Acetaminophen Glucuronide Sodium Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements for pharmaceutical reference standards. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identification (IR, NMR), and impurity profiles is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.