Description

Leinamycin CAS NO 120500-15-4 is a potent, naturally occurring antitumor antibiotic isolated from *Streptomyces* species. This compound is of significant interest in pharmaceutical research and development due to its unique mechanism of action, which involves DNA alkylation and cleavage, leading to potent cytotoxic effects. It serves as a critical reference standard and a valuable building block for researchers in oncology, medicinal chemistry, and biochemistry, enabling the study of novel anticancer agents and mechanisms.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in drug discovery and development.
• Anticancer Research: Serves as a key biochemical tool for studying DNA damage and repair mechanisms, apoptosis induction, and evaluating the efficacy of novel therapeutic strategies.
• Medicinal Chemistry: Acts as a lead compound or a synthetic intermediate for the design and synthesis of new analogs with improved potency, selectivity, or pharmacokinetic profiles.
• Mechanistic Studies: Utilized in biochemical assays to investigate the specific interactions between enediyne antibiotics and their cellular targets.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental research in chemical biology, oncology, and molecular pharmacology.

Basic Information

Item	Details
Product Name	Leinamycin
CAS No.	120500-15-4
Molecular Formula	C₃₀H₄₀N₂O₈S₂
Molecular Weight	620.78 g/mol
Synonyms	Leinamycin; LNM; Antibiotic LNM; (1R,2S,3S,4R,5S,6S,7S,8R,9S,10S,11S,12R,13S,14S,15S,16R,17S,18S,19S,20R)-5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20-Hexadecahydro-1,4,8,11,15,18-hexamethyl-3-[(1E)-1-propen-1-yl]-2H-1,10,13,16-tetraoxa-7,14-dithia-4,11,15,18-tetraazacycloeicosine-2,19-dione; U-62162
EINECS	Contact for details

Quality Control

Every batch of Leinamycin is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our quality control process includes comprehensive analytical testing via HPLC, NMR, and MS to meet the exacting standards required for research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.