Description

Calphostin A is a potent, cell-permeable inhibitor of protein kinase C (PKC) that is structurally unique as a perylenequinone natural product. Its primary value lies in its high specificity and potency, making it a critical research tool for studying signal transduction pathways in cellular biology and biochemistry. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for investigating cancer mechanisms, cardiovascular diseases, and neurological disorders.

Application

• Biochemical Research: A standard tool for selectively inhibiting Protein Kinase C (PKC) isoforms in cell-based assays and enzymatic studies.
• Oncology Research: Used to investigate the role of PKC in tumor cell proliferation, apoptosis, and metastasis signaling pathways.
• Neuroscience Studies: Applied in research on neurotransmitter release, synaptic plasticity, and the molecular basis of neurological diseases where PKC is implicated.
• Cardiovascular Research: Employed to study PKC-mediated processes in cardiac hypertrophy, vascular smooth muscle contraction, and endothelial function.
• Pharmacology & Drug Discovery: Serves as a reference compound and positive control in high-throughput screening for novel PKC inhibitor development.
• Cell Signaling Pathway Analysis: Utilized to dissect complex intracellular signaling networks and cross-talk involving the PKC family.

Basic Information

Product Name	Calphostin A
CAS No.	120461-92-9
Molecular Formula	C40H34O10
Molecular Weight	674.69 g/mol
Synonyms	UCN-1028A; NSC 693501; 1,6,11,16-Tetrahydroxy-3,8,13,18-tetramethyl-4,9,14,19-tetraoxo-4,9,14,19-tetrahydroperylene-2,7,12,17-tetracarbaldehyde; Perylenequinone PKC Inhibitor; Calphostin A from Cladosporium cladosporioides
EINECS	Contact for details

Quality Control

Our Calphostin A is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant standards for research chemicals, ensuring reliability for critical scientific investigations.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep the primary container sealed within a secondary, light-proof container.

Specification

Item	Specification
Appearance	Dark green to black powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.