Description

6-Methoxyvesamicol is a vesicular acetylcholine transporter (VAChT) inhibitor, a key research compound in neurochemical studies. Its primary value lies in its utility as a potent and selective pharmacological tool for investigating cholinergic neurotransmission, synaptic vesicle function, and related neurological disorders. This makes it essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on neuroscience, drug discovery, and diagnostic agent development.

Application

• Neuroscience Research: A critical tool for studying the cholinergic system, synaptic vesicle packaging, and release mechanisms of acetylcholine.
• Pharmacological Probe Development: Used in the design and screening of novel ligands targeting the vesicular acetylcholine transporter (VAChT).
• Neurodegenerative Disease Models: Applied in preclinical research for conditions like Alzheimer's disease, myasthenia gravis, and other disorders involving cholinergic deficit.
• Radiopharmaceutical Precursor: Serves as a precursor or reference compound in the development of positron emission tomography (PET) tracers for imaging VAChT density in the brain.
• Biochemical Assay Standard: Used as a reference standard in competitive binding assays and other in vitro studies to quantify VAChT activity or inhibitor potency.

Basic Information

Product Name	6-Methoxyvesamicol
CAS No.	120447-25-8
Molecular Formula	C20H25NO2
Molecular Weight	311.42 g/mol
Synonyms	(–)-6-Methoxyvesamicol; (2R,3R)-6-Methoxy-3-(4-phenylpiperidino)-1,2,3,4-tetrahydro-2-naphthol; 6-Methoxy-VAT; 6-OMe-Vesamicol; VAChT Inhibitor (6-Methoxy); (-)-trans-2-Hydroxy-6-methoxy-3-(4-phenylpiperidino)tetralin
EINECS	Contact for details

Quality Control

Our 6-Methoxyvesamicol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identity confirmation (IR, NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.