Description

D-[5-13C]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 5th position. This high-purity compound is essential for advanced metabolic research, enabling precise tracing and quantification of glucose utilization and metabolic flux in biological systems. It is a critical reagent for scientists and manufacturers in pharmaceutical R&D, clinical diagnostics, and academic research focused on metabolism, diabetes, and cancer biology.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify intracellular metabolic pathways in cell cultures, tissues, and whole organisms.
• Drug Discovery & Development: Employed in preclinical studies to investigate the effects of new drug candidates on cellular energy metabolism and glycolysis.
• Clinical Research & Diagnostics: Serves as a substrate in in vivo metabolic tests, such as stable isotope breath tests, to assess glucose metabolism disorders.
• NMR & Mass Spectrometry: Acts as an internal standard or labeled substrate for quantitative analysis using Nuclear Magnetic Resonance (NMR) spectroscopy and LC/MS or GC/MS platforms.
• Biochemical Research: Utilized in enzyme kinetics studies to elucidate the mechanisms of glycolytic and pentose phosphate pathway enzymes.
• Nutritional Science: Applied in studies investigating glucose absorption, turnover, and utilization in nutritional and exercise physiology.

Basic Information

Product Name	D-[5-13C]Glucose
CAS No.	120388-24-1
Molecular Formula	C6H12O6 (with 13C at position 5)
Molecular Weight	181.15 g/mol (for 13C1 isotopologue)
Synonyms	D-Glucose-5-13C; (5-13C)Glucose; 5-13C-Labeled D-glucose; D-Glucose (5-13C); [5-13C]D-Glucose; Dextrose-5-13C; Isotope-labeled glucose; Stable isotope-labeled D-glucose
EINECS	Contact for details

Quality Control

Our D-[5-13C]Glucose is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity, and analytical results from techniques such as NMR and HPLC. We adhere to relevant industry standards for fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.