Description

Unoprostone is a synthetic prostaglandin F2α analog, a high-purity active pharmaceutical ingredient (API) with significant therapeutic applications. Its primary value lies in its potent biological activity, specifically as a selective FP prostanoid receptor agonist, making it a critical component in advanced ophthalmic formulations. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing treatments for ocular conditions, particularly glaucoma and ocular hypertension.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription ophthalmic solutions for lowering intraocular pressure.
• Key component in glaucoma therapeutics, used in the formulation of eye drops such as Rescula®.
• Research chemical for pharmacological studies on prostaglandin receptors and ocular drug delivery systems.
• Reference standard for quality control and analytical method development in pharmaceutical laboratories.
• Intermediate in the synthesis of novel prostaglandin analogs and related bioactive molecules.

Basic Information

Product Name	Unoprostone
CAS No.	120373-36-6
Molecular Formula	C₂₂H₃₅FO₅
Molecular Weight	398.51 g/mol
Synonyms	Unoprostone Isopropyl; UF-021; 13,14-Dihydro-15-deoxy-17,17,18,18,19,19,20,20,20-nonafluoro-20-ethyl-PGF2α isopropyl ester; Isopropyl (Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-3-(3,3,4,4,5,5,6,6,6-nonafluorohexyloxy)-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoate; Rescula (Brand Name)
EINECS	Contact for details

Quality Control

Our Unoprostone is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and specific identification tests. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with relevant guidelines. We support development and commercial projects requiring material that meets stringent ICH Q3 impurity control standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.