Description

Diacylglycerol Kinase Inhibitor II is a potent and selective cell-permeable inhibitor of diacylglycerol kinase (DGK) isoforms, specifically targeting the alpha and gamma subtypes. This compound is a critical research tool for modulating diacylglycerol (DAG) and phosphatidic acid (PA) signaling pathways, which are central to cellular processes like proliferation, apoptosis, and immune response. It is primarily utilized by researchers and pharmaceutical developers in the fields of cell biology, immunology, and oncology to investigate lipid-mediated signal transduction and identify potential therapeutic targets.

Application

• Biochemical Research: A key tool for studying the role of diacylglycerol kinases (DGKs) in lipid second messenger signaling cascades.
• Immunology Studies: Used to investigate T-cell receptor signaling, T-cell anergy, and immune cell activation mechanisms.
• Cancer Research: Employed in preclinical studies to explore the involvement of DGK isoforms in tumor cell proliferation, survival, and metastasis.
• Neuroscience Research: Applied in models to understand synaptic plasticity, neurotransmitter release, and neuronal differentiation regulated by DAG signaling.
• Drug Discovery: Serves as a reference compound and pharmacological probe for validating new DGK inhibitors in high-throughput screening assays.
• Cell Signaling Pathway Analysis: Facilitates the dissection of complex signaling networks involving phospholipase C, protein kinase C, and mTOR pathways.

Basic Information

Product Name	Diacylglycerol Kinase Inhibitor II
CAS No.	120166-69-0
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	R 59949; R59949; DGK Inhibitor II; 3-{2-[4-(Bis-(4-fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)-quinazolinone; 2-Thioxo-3-[2-[4-(bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-4(3H)-quinazolinone; Diacylglycerol Kinase alpha/gamma Inhibitor; 1-Piperidineacetamide, N-(2,3-dihydro-2-thioxo-4(1H)-quinazolinyl)-4,4'-(fluorophenylmethylene)bis-
EINECS	Contact for details

Quality Control

Our Diacylglycerol Kinase Inhibitor II is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.