Description

(Glutathion-S-Yl)Dihydromorphinone is a specialized biochemical conjugate of the opioid alkaloid dihydromorphinone with the tripeptide glutathione. This compound is of significant interest in advanced pharmacological research, particularly for studying drug metabolism, detoxification pathways, and the formation of protein adducts. It serves as a critical reference standard and research tool for scientists in pharmaceutical development, forensic toxicology, and biochemical research.

Application

• Metabolite Reference Standard: Used as an analytical standard in LC-MS and HPLC methods for the identification and quantification of glutathione-conjugated opioid metabolites in biological samples.
• Toxicology Research: Essential for investigating the mechanisms of opioid-induced hepatotoxicity and the role of glutathione in cellular detoxification processes.
• Pharmacokinetic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the metabolic fate of dihydromorphinone and related opioids.
• Biomarker Development: Aids in the development of specific biomarkers for opioid abuse or overdose by studying stable adduct formation.
• Enzymology Studies: Used as a substrate to study the activity of glutathione S-transferase (GST) enzymes and their role in Phase II metabolism.
• Forensic Analysis: Provides a key reference material for confirmatory testing in forensic laboratories analyzing complex drug metabolites.

Basic Information

Product Name	(Glutathion-S-Yl)Dihydromorphinone
CAS No.	119995-15-2
Molecular Formula	C30H39N5O10S
Molecular Weight	661.73 g/mol
Synonyms	Glutathionyl Dihydromorphinone; Dihydromorphinone Glutathione Conjugate; GSH-Dihydromorphinone Adduct; 14-Hydroxy-7,8-dihydromorphinone Glutathion-S-yl Adduct; Opioid-Glutathione Conjugate; CAS 119995-15-2; Hydromorphone Glutathione Adduct
EINECS	Contact for details

Quality Control

Every batch of (Glutathion-S-Yl)Dihydromorphinone is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous identity confirmation, purity analysis, and stability testing to ensure they meet the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.