Description

3-Pyridinecarbonyl Chloride, 2-(Trifluoromethyl)- (9Ci) is a high-value, reactive heterocyclic building block. This compound is critical for introducing the 2-(trifluoromethyl)nicotinoyl moiety into target molecules, a key structural motif in modern pharmaceutical and agrochemical discovery. It is primarily sought after by research chemists and process development scientists in the life sciences sector for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethylpyridine unit enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized pyridine-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials that require specific aromatic carboxylic acid derivatives.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis organizations (CSOs) and CDMOs serving the global pharmaceutical and agrochemical industries.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 2-(Trifluoromethyl)- (9Ci)
CAS No.	119899-27-3
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2-(Trifluoromethyl)nicotinoyl chloride; 2-(Trifluoromethyl)pyridine-3-carbonyl chloride; 3-Carbamoyl-2-(trifluoromethyl)pyridine hydrochloride (related); Nicotinoyl chloride, 2-(trifluoromethyl)-; 2-Trifluoromethylnicotinic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonyl Chloride, 2-(Trifluoromethyl)- is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.