Description

3-Pyridinecarbonyl Chloride, 2-Fluoro- (9Ci) is a high-value fluorinated pyridine derivative and an essential acyl chloride building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the 2-fluoro-nicotinoyl moiety, a key structural motif that can significantly alter the physicochemical and biological properties of target molecules. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the fluorine atom enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic properties.
• Peptide & Protein Modification: Facilitates the site-specific acylation of amino groups in peptides and biomolecules for biochemical studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the life sciences sector.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 2-Fluoro- (9Ci)
CAS No.	119899-26-2
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	2-Fluoronicotinoyl Chloride; 2-Fluoropyridine-3-carbonyl Chloride; 2-Fluoro-3-pyridinecarbonyl Chloride; 2-Fluoronicotinic Acid Chloride; 2-Fluoro-3-pyridinecarboxylic Acid Chloride; 2-Fluoropyridine-3-carboxylic Acid Chloride; 2-Fluoro-3-chlorocarbonylpyridine; 2-Fluoronicotinyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonyl Chloride, 2-Fluoro- is produced and analyzed under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.