Description

11-Deazahomofolic Acid is a synthetic analog of folic acid, representing a key intermediate in the research and development of novel therapeutic agents. This compound is of significant interest for its role in studying enzyme inhibition and metabolic pathways, particularly those involving folate-dependent processes. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential antifolate drugs and enzyme inhibitors.
• Biochemical Research: Used as a tool compound in enzymatic studies to investigate the mechanism of dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Oncology Research: Explored in the development of targeted cancer therapies that interfere with nucleotide synthesis in rapidly dividing cells.
• Academic Studies: Employed in university and institutional labs for fundamental research in medicinal chemistry and chemical biology.
• Reference Standard: Can be used as a high-purity analytical standard for method development and quality control in related API manufacturing.

Basic Information

Product Name	11-Deazahomofolic Acid
CAS No.	119770-54-6
Molecular Formula	C₂₁H₂₃N₇O₅
Molecular Weight	453.46 g/mol
Synonyms	N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-homoglutamic Acid; 11-Deaza-homofolic Acid; 11-Deaza-DL-homofolate; Homofolic Acid, 11-Deaza-; L-Homoglutamic Acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; 11-Deazaaminopterin analog
EINECS	Contact for details

Quality Control

Our 11-Deazahomofolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.