Description

Homoharringtonamide is a synthetic derivative of the natural cephalotaxine alkaloid, harringtonine, known for its potent biological activity. This compound is a key intermediate and reference standard in pharmaceutical research and development, particularly in the study of anti-leukemic agents. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on oncology drug discovery and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and analytical method validation of related anti-cancer therapeutics.
• Oncology Research: Serves as a critical biochemical tool and intermediate in the research and development of novel chemotherapeutic agents targeting leukemia.
• Mechanistic Studies: Employed in preclinical studies to investigate apoptosis induction and protein synthesis inhibition in cancer cell lines.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a key synthetic precursor in the production of more complex harringtonine analogs for clinical evaluation.

Basic Information

Product Name	Homoharringtonamide
CAS No.	119767-03-2
Molecular Formula	C29H39NO9
Molecular Weight	545.62 g/mol
Synonyms	Homoharringtonine amide; Harringtonine amide derivative; Cephalotaxine, 4-methyl-2-hydroxy-2,4-pentanedioate 5-ester with 4,6-O-[(1R)-1-carbamoyl-2-methylpropylidene]-2,3-di-O-methyl-; (3'R)-4'-dimethyl-2'-hydroxy-2',4'-pentanedioic acid 5-ester with 4,6-O-[(1R)-1-carbamoyl-2-methylpropylidene]-2,3-di-O-methylcephalotaxine
EINECS	Contact for details

Quality Control

Our Homoharringtonamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.