Description

Sertraline Carbamoyl Glucuronide is a key metabolite of the widely prescribed antidepressant sertraline. This compound is of significant importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, metabolite identification, and regulatory compliance testing.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of sertraline metabolites in biological matrices (e.g., plasma, urine) using LC-MS/MS or HPLC.
• Metabolite Profiling and Identification: Essential for in vitro and in vivo studies aimed at mapping the metabolic pathways of sertraline, supporting drug safety assessments.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Used to investigate the exposure-response relationship of sertraline and its active metabolites.
• Impurity Characterization: Acts as an impurity standard in the quality control of sertraline active pharmaceutical ingredient (API) to monitor and control related substances.
• Clinical Trial Support: Employed in the bioanalytical phase of clinical trials to ensure accurate measurement of metabolite levels for regulatory submissions.
• Toxicology Studies: Facilitates research into the potential toxicological implications of sertraline metabolism.

Basic Information

Item	Details
Product Name	Sertraline Carbamoyl Glucuronide
CAS No.	119733-44-7
Molecular Formula	C25H30Cl2N2O9
Molecular Weight	573.42 g/mol
Synonyms	Sertraline N-Carbamoyl Glucuronide; (1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine Carbamoyl Glucuronide; Sertraline N-Carbamoyl-β-D-glucuronide; Zoloft Metabolite (Carbamoyl Glucuronide); Sertraline N-Carbamoyl Glucuronide Conjugate; SCG; Sertraline Metabolite M4
EINECS	Contact for details

Quality Control

Our Sertraline Carbamoyl Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, LC-MS confirmation, and NMR structural verification, to ensure identity, potency, and purity meet the stringent requirements for reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.