Description

Z-Leu-Val-Gly-Diazomethylketone is a specialized, high-purity peptide-based diazomethyl ketone, a potent and irreversible inhibitor of cysteine proteases. This compound is critical for researchers and manufacturers requiring precise enzyme inhibition in biochemical pathways. It is primarily utilized in pharmaceutical R&D, proteomics research, and the development of therapeutic agents targeting cathepsins and other cysteine-dependent enzymes.

Application

• Biochemical Research: As a selective, irreversible inhibitor for mechanistic studies of cysteine proteases like cathepsins B, L, and S.
• Pharmaceutical Development: Used in the discovery and validation of novel drug targets for conditions involving protease dysregulation, such as cancer metastasis, osteoporosis, and inflammatory diseases.
• Proteomics & Enzyme Profiling: A key tool for activity-based protein profiling (ABPP) to identify and characterize active cysteine proteases in complex biological samples.
• Antiviral Agent Research: Investigated for its potential to inhibit viral proteases critical for the replication of certain viruses.
• Production of Reference Standards: Serves as a high-purity chemical reference standard for quality control in related pharmaceutical manufacturing.

Basic Information

Product Name	Z-Leu-Val-Gly-Diazomethylketone
CAS No.	119670-30-3
Molecular Formula	C₂₂H₃₁N₅O₆
Molecular Weight	461.52 g/mol
Synonyms	Z-Leu-Val-Gly-CHN₂; Z-Leu-Val-Gly-Diazomethane; Benzyloxycarbonyl-Leucyl-Valyl-Glycine Diazomethyl Ketone; Z-LVG-CHN₂; Cathepsin Inhibitor; Cbz-Leu-Val-Gly-Diazomethylketone; N-[(Benzyloxy)carbonyl]-L-leucyl-L-valylglycine 2-diazo-1-oxoethyl ester
EINECS	Contact for details

Quality Control

Our Z-Leu-Val-Gly-Diazomethylketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and stringent controls for moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.