Description

7-Ethyl-10-Hydroxycamptothecin, 98% is a high-purity derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is a critical pharmaceutical intermediate valued for its role in the research and development of novel anticancer therapeutics. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of camptothecin-derived anticancer agents.
• Biochemical Research: Used as a reference standard and active compound in studies targeting topoisomerase I enzyme inhibition.
• Anticancer Drug Development: Serves as a precursor for the development and optimization of novel chemotherapeutic compounds.
• Analytical Standard: Employed in HPLC, LC-MS, and other analytical methods for quality control and method validation in pharmaceutical manufacturing.
• Academic Research: Utilized in university and institutional labs for investigating mechanisms of apoptosis and cell cycle arrest.

Basic Information

Product Name	7-Ethyl-10-Hydroxycamptothecin, 98%
CAS No.	119577-28-5
Molecular Formula	C22H20N2O5
Molecular Weight	392.41 g/mol
Synonyms	10-Hydroxy-7-ethylcamptothecin; SN-38; 7-Ethyl-10-hydroxycamptothecin; Irinotecan Active Metabolite; (S)-10-Hydroxy-7-ethylcamptothecin; CPT-11 Active Form; 7-Ethyl-10-hydroxy-20(S)-camptothecin; 119577-28-5
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Hydroxycamptothecin, 98% is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the specified 98% minimum purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere if specified and handled in low-humidity conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.