Description

Atpenin B CAS NO 119509-26-1 is a potent and selective inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase). This compound matters for researchers as a critical pharmacological tool for studying cellular respiration, metabolic pathways, and oxidative stress. It is primarily needed by scientists in the fields of biochemistry, pharmacology, and molecular biology for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a specific inhibitor to study the function and role of mitochondrial complex II (succinate dehydrogenase) in electron transport chains.
• Metabolic Pathway Analysis: Essential for investigating cellular metabolism, energy production, and the metabolic shifts associated with various disease states.
• Pharmacology & Drug Discovery: Serves as a reference compound for screening and developing novel therapeutic agents targeting mitochondrial dysfunction.
• Cancer Research: Applied in studies exploring the link between mitochondrial metabolism, reactive oxygen species (ROS) generation, and cancer cell proliferation or survival.
• Neurodegenerative Disease Models: Utilized in research models to induce mitochondrial impairment and study its implications in conditions like Parkinson's or Alzheimer's disease.
• Academic & Industrial R&D: A key reagent for basic scientific research and applied development in biotechnology and pharmaceutical companies worldwide.

Basic Information

Product Name	Atpenin B
CAS No.	119509-26-1
Molecular Formula	C22H30O6
Molecular Weight	390.47 g/mol
Synonyms	Atpenin B; Atpenin B5; 2-Heptyl-4-hydroxyquinoline N-oxide; HQNO derivative; Mitochondrial Complex II Inhibitor; Succinate Dehydrogenase Inhibitor; Antibiotic A 82548B
EINECS	Contact for details

Quality Control

Our Atpenin B is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.