Description

Atpenin A5 is a potent and selective inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase). This compound is a critical research tool for studying cellular bioenergetics, oxidative stress, and metabolic pathways. It is primarily utilized by researchers in the fields of biochemistry, pharmacology, and molecular biology for investigating mitochondrial dysfunction and its role in various disease models.

Application

• Biochemical Research: A key tool for selectively inhibiting mitochondrial complex II to study electron transport chain function and ATP production.
• Pharmacological Studies: Used to investigate the role of mitochondrial metabolism in disease pathologies, including cancer, neurodegenerative disorders, and ischemia-reperfusion injury.
• Cell Biology: Employed in experiments to dissect the contribution of complex II to reactive oxygen species (ROS) generation and cellular redox signaling.
• Metabolic Pathway Analysis: Facilitates the study of metabolic flexibility and the switch between glycolysis and oxidative phosphorylation in various cell types.
• Drug Discovery Screening: Serves as a reference compound in high-throughput assays targeting mitochondrial function for therapeutic development.

Basic Information

Product Name	Atpenin A5
CAS No.	119509-24-9
Molecular Formula	C19H16O8
Molecular Weight	372.33 g/mol
Synonyms	Atpenin A5; 2-Heptyl-4-hydroxyquinoline N-oxide; HQNO Heptyl Derivative; 2-Heptyl-4-hydroxyquinoline 1-oxide; Mitochondrial Complex II Inhibitor A5; Succinate Dehydrogenase Inhibitor A5
EINECS	Contact for details

Quality Control

Our Atpenin A5 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.