Description

Dansylglutamyl-Glycyl-Arginyl Chloromethyl Ester CAS NO 119206-61-0 is a specialized, high-purity peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a key reagent in the synthesis of complex molecules and diagnostic probes. It is primarily utilized by researchers and manufacturers in the fields of proteomics, enzymology, and medicinal chemistry for studying enzyme mechanisms and developing novel therapeutic agents.

Application

• Protease Substrate & Inhibitor Development: Acts as a specific, fluorogenic substrate for studying the activity and kinetics of serine proteases like thrombin and trypsin.
• Biochemical Assay Reagent: Used in high-throughput screening (HTS) assays to identify and characterize potential enzyme inhibitors for drug discovery.
• Peptide Synthesis Intermediate: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for creating larger, biologically active peptides.
• Fluorescent Labeling & Detection: The dansyl fluorophore enables sensitive detection and quantification in fluorescence-based analytical techniques.
• Diagnostic Kit Component: Incorporated into in-vitro diagnostic (IVD) kits for clinical measurement of specific protease levels.
• Academic & Industrial Research: Essential tool for fundamental research in biochemistry, cell signaling pathways, and disease mechanism studies.

Basic Information

Product Name	Dansylglutamyl-Glycyl-Arginyl Chloromethyl Ester
CAS No.	119206-61-0
Molecular Formula	C30H45ClN8O8S
Molecular Weight	713.24 g/mol
Synonyms	Dansyl-Glu-Gly-Arg-CH2Cl; Dns-Glu-Gly-Arg-CH2Cl; (5-Dimethylaminonaphthalene-1-sulfonyl)-L-glutamyl-glycyl-NG-nitro-L-arginine chloromethyl ester; DGR-CK; Thrombin Substrate III (Fluorogenic); Fluorogenic Thrombin Substrate; Protease Fluorogenic Substrate; Chloromethyl Ketone Inhibitor Precursor
EINECS	Contact for details

Quality Control

Our Dansylglutamyl-Glycyl-Arginyl Chloromethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.