Description

Inositol 1,4,5-Trisphosphate 1-(2-Nitrophenyl)Ethyl Ester is a caged, photolabile derivative of the critical secondary messenger IP3, designed for precise temporal and spatial control of intracellular calcium release in biological research. This compound matters because it enables researchers to trigger and study calcium-dependent signaling pathways with high precision using UV light, a technique essential for understanding cellular physiology, neurobiology, and pharmacology. It is primarily needed by life science researchers, pharmaceutical developers, and academic institutions engaged in advanced cell signaling studies, drug discovery for calcium-related disorders, and neurobiological investigations.

Application

• Cell Signaling Research: As a caged compound for the controlled, light-induced release of IP3 to study intracellular calcium (Ca²⁺) dynamics and signaling cascades.
• Neuroscience & Neuropharmacology: For investigating the role of IP3 receptors in neuronal communication, synaptic plasticity, and models of neurological diseases.
• Drug Discovery & Screening: Used in high-content screening assays to identify and validate novel therapeutics targeting GPCR pathways and calcium homeostasis.
• Cardiovascular Research: To examine IP3-mediated calcium signaling in cardiac myocytes and vascular smooth muscle cells.
• Developmental Biology: For probing the spatial and temporal patterns of calcium signaling during embryogenesis and cell differentiation.
• Biochemical Tool Development: Serves as a critical reagent in developing new assay kits and experimental methodologies for calcium imaging.

Basic Information

Product Name	Inositol 1,4,5-Trisphosphate 1-(2-Nitrophenyl)Ethyl Ester
CAS No.	119147-21-6
Molecular Formula	C₂₁H₂₄N₂O₁₈P₃
Molecular Weight	678.33 g/mol
Synonyms	IP3, 1,4,5-Trisphosphate Caged Compound; caged IP3; D-myo-Inositol 1,4,5-trisphosphate, P⁴⁵-(1-(2-nitrophenyl)ethyl) ester; Ins(1,4,5)P₃ caged; NP-E-caged IP₃; 1-[2-Nitrophenyl]ethyl ester of D-myo-inositol 1,4,5-trisphosphate; caged inositol trisphosphate
EINECS	Contact for details

Quality Control

Our Inositol 1,4,5-Trisphosphate 1-(2-Nitrophenyl)Ethyl Ester is produced under stringent conditions to ensure the highest standards of purity and biological activity required for sensitive research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic verification of structure. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.