Description

Fumitremorgin C is a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). This compound matters significantly for researchers investigating multidrug resistance in cancer therapy and studying the pharmacokinetics of various drugs. It is primarily needed by pharmaceutical R&D teams, academic institutions, and contract research organizations focused on oncology, neuropharmacology, and drug transporter biology. Fumitremorgin C CAS NO 118974-02-0 serves as a critical pharmacological tool for in vitro and in vivo studies.

Application

• Cancer Research: Used to study and overcome BCRP-mediated multidrug resistance in various cancer cell lines.
• Pharmacokinetics & Drug Disposition: Employed as a probe to investigate the role of BCRP in the absorption, distribution, and excretion of substrate drugs.
• Blood-Brain Barrier Studies: Applied in research to understand BCRP's function at the blood-brain barrier and its impact on central nervous system drug delivery.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening assays for BCRP inhibition.
• Academic & Preclinical Research: A key tool for fundamental research into ABC transporter biology and function.

Basic Information

Product Name	Fumitremorgin C
CAS No.	118974-02-0
Molecular Formula	C22H27N3O3
Molecular Weight	381.47 g/mol
Synonyms	FTC; Fumitremorgin C; (3S,6aS,10aR)-3-(1H-Indol-3-ylmethyl)-6a,10a-dihydroxy-1,2,3,5,6,6a,10,10a-octahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine-7,9-dione; Ko 143; BCRP Inhibitor III; ABCG2 Inhibitor
EINECS	Contact for details

Quality Control

Our Fumitremorgin C is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.