Description

Kelatorphan is a potent and selective inhibitor of the enzyme neprilysin (NEP), also known as neutral endopeptidase 24.11. This compound is of significant value in biochemical and pharmacological research for its ability to modulate the degradation of endogenous peptides, including enkephalins and natriuretic peptides. It is primarily utilized by researchers and developers in the fields of neuroscience, cardiovascular research, and drug discovery to study pain pathways, memory, and heart failure mechanisms.

Application

• Neuroscience Research: Used to study the role of enkephalins and other neuropeptides in pain modulation, addiction, and memory by inhibiting their enzymatic degradation.
• Cardiovascular Research: Employed to investigate the effects of natriuretic peptides on blood pressure regulation and heart function through NEP inhibition.
• Drug Discovery & Development: Serves as a key reference standard and pharmacological tool in the development of novel NEP inhibitors for therapeutic applications.
• Biochemical Assays: Acts as a critical reagent in enzymatic assays to determine NEP activity and screen for potential inhibitors.
• Metabolic Pathway Studies: Utilized to elucidate the metabolic fate of bioactive peptides in various in vitro and ex vivo experimental models.

Basic Information

Product Name	Kelatorphan
CAS No.	118867-26-8
Molecular Formula	C₁₇H₂₄N₂O₄
Molecular Weight	320.38 g/mol
Synonyms	N-[(2R)-2-(Hydroxyaminocarbonylmethyl)-4-methylpentanoyl]-L-tryptophanamide; (R)-N-[(R)-2-(Hydroxyaminocarbonylmethyl)-4-methylpentanoyl]-L-tryptophanamide; Kelatorphan; Thiorphan Hydroxamate; Neprilysin Inhibitor; NEP Inhibitor; EC 3.4.24.11 Inhibitor; Enkephalinase Inhibitor
EINECS	Contact for details

Quality Control

Our Kelatorphan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.