Description

Candoxatril is a potent and selective inhibitor of neutral endopeptidase (NEP), an enzyme involved in the degradation of natriuretic peptides. This compound is a critical intermediate in the synthesis of the prodrug Candoxatrilat, which has been investigated for its therapeutic potential in cardiovascular conditions such as hypertension and heart failure. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel cardiovascular agents. The material is supplied as a high-purity reference standard and building block for advanced pharmaceutical synthesis.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the production of the NEP inhibitor prodrug, Candoxatrilat.
• Research & Development: Used as a reference standard and active pharmacophore in cardiovascular drug discovery programs.
• Biochemical Research: Serves as a selective tool compound for studying the role of neutral endopeptidase in physiological and pathophysiological processes.
• Fine Chemical Synthesis: Employed as a specialized building block for creating novel analogs and derivatives with potential therapeutic activity.

Basic Information

Product Name	Candoxatril
CAS No.	118785-03-8
Molecular Formula	C23H30N2O5
Molecular Weight	414.50 g/mol
Synonyms	(2R,4R)-4-([1,1'-Biphenyl]-4-yl)-2-[(phenylmethoxy)carbonyl]-1-[2-(ethoxycarbonyl)ethyl]piperidine; UK-79,300; Candoxatrilum; (2R,4R)-1-[2-(Ethoxycarbonyl)ethyl]-4-(4-phenylphenyl)-2-[(phenylmethoxy)carbonyl]piperidine
EINECS	Contact for details

Quality Control

Our Candoxatril CAS NO 118785-03-8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical development and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.