Description

2-Fluoro-4-Methylbenzyl Bromide is a versatile and reactive organobromine building block. Its molecular structure, featuring both a reactive benzyl bromide group and a fluorine substituent, makes it a critical intermediate for introducing the 2-fluoro-4-methylbenzyl moiety into more complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity intermediates for synthesis. It is particularly valued in the development of active pharmaceutical ingredients (APIs) and advanced material precursors.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in medicinal chemistry for creating fluorinated analogs.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays.
• Cross-Coupling Reactions: Employed in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Functional Material Research: Utilized in R&D for creating specialty polymers, ligands, and organic frameworks with tailored properties.
• Chemical Derivatization: Acts as an alkylating agent to introduce the 2-fluoro-4-methylbenzyl group into various nucleophiles like amines and phenols.

Basic Information

Product Name	2-Fluoro-4-Methylbenzyl Bromide
CAS No.	118745-63-4
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-4-methylbenzene; α-Bromo-2-fluoro-4-methyltoluene; 2-Fluoro-α-bromo-p-xylene; (2-Fluoro-4-methylphenyl)methyl bromide; 4-Methyl-2-fluorobenzyl bromide; 2-Fluoro-4-methylbenzylbromide; 2-Fluoro-p-methylbenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methylbenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.