Description

Mk-886 CAS NO 118427-55-7 is a potent and selective inhibitor of the 5-lipoxygenase-activating protein (FLAP), a key target in the leukotriene biosynthesis pathway. This compound is crucial for researchers and developers investigating inflammatory and allergic responses, as it helps elucidate the role of leukotrienes in disease pathology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutics for conditions like asthma, arthritis, and other inflammatory disorders.

Application

• Pharmaceutical Research & Development: Serves as a critical biochemical tool for studying the 5-lipoxygenase pathway and validating FLAP as a therapeutic target.
• Inflammation & Immunology Studies: Used in in vitro and in vivo models to investigate the mechanisms of leukotriene-mediated inflammatory and allergic diseases.
• Drug Discovery Screening: Acts as a reference standard or positive control in high-throughput screening assays for identifying new anti-inflammatory agents.
• Academic & Preclinical Research: Employed in university and institutional labs for fundamental research into eicosanoid biology and signal transduction.
• Biochemical Reagent: Used as a specific inhibitor to dissect complex biological pathways involving arachidonic acid metabolism.

Basic Information

Product Name	Mk-886
CAS No.	118427-55-7
Molecular Formula	C28H34ClNO3S
Molecular Weight	500.10 g/mol
Synonyms	MK-886; MK886; L-663,536; 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropanoic acid; FLAP inhibitor; 5-Lipoxygenase-activating protein inhibitor; Indole-2-propanoic acid derivative
EINECS	Contact for details

Quality Control

Our Mk-886 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.