Description

Mk-886 CAS NO 118414-82-7 is a potent and selective inhibitor of the 5-lipoxygenase-activating protein (FLAP), a key target in the leukotriene biosynthesis pathway. This compound is crucial for researchers investigating inflammatory and allergic responses, as it helps elucidate the role of leukotrienes in various disease models. It is primarily utilized by pharmaceutical R&D teams, academic institutions, and contract research organizations (CROs) focused on developing novel anti-inflammatory therapeutics.

Application

• Biochemical Research: A critical tool for studying the 5-lipoxygenase pathway and leukotriene-mediated signaling in cellular models of inflammation.
• Pharmacology Studies: Used in in vitro and in vivo experiments to validate FLAP as a therapeutic target for conditions like asthma, atherosclerosis, and arthritis.
• Drug Discovery & Development: Serves as a reference standard and lead compound in screening assays for novel FLAP inhibitors.
• Academic Research: Employed in university laboratories to investigate the molecular mechanisms of inflammatory diseases and immune responses.
• Preclinical Development: Supports efficacy and mechanism-of-action studies in animal models relevant to inflammatory disorders.

Basic Information

Product Name	Mk-886
CAS No.	118414-82-7
Molecular Formula	C₂₉H₃₈N₂O₃
Molecular Weight	462.62 g/mol
Synonyms	MK-886; MK886; 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid; L-663,536; FLAP Inhibitor I; 5-Lipoxygenase-Activating Protein Inhibitor; Indole-2-propanoic acid derivative
EINECS	Contact for details

Quality Control

Our Mk-886 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.