Description

Tyrphostin Ag 126 CAS NO 118409-62-4 is a potent and selective inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR) pathway. This compound is a critical research tool for studying intracellular signal transduction mechanisms related to cell proliferation, differentiation, and apoptosis. It is primarily utilized by researchers and scientists in the fields of biochemistry, pharmacology, and oncology for in vitro and in vivo studies.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study signal transduction pathways.
• Cancer Research: Investigated for its effects on tumor cell growth and proliferation in various cancer models.
• Pharmacology Studies: Employed to understand drug mechanisms and to develop potential therapeutic agents targeting tyrosine kinases.
• Cell Biology: Applied in studies of cell cycle regulation, apoptosis (programmed cell death), and cellular differentiation.
• Academic & Institutional R&D: A standard reagent in university and research institute laboratories for fundamental biological research.
• Pharmaceutical Development: Serves as a reference compound or lead molecule in early-stage drug discovery programs.

Basic Information

Item	Detail
Product Name	Tyrphostin Ag 126
CAS No.	118409-62-4
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 126; Tyrphostin AG 126; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; α-Cyano-3,4-dihydroxy-N-benzylcinnamamide; Benzyl (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoate; EGFR Tyrosine Kinase Inhibitor AG126; NSC 645809
EINECS	Contact for details

Quality Control

Our Tyrphostin Ag 126 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and assay results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere or desiccated upon opening for long-term stability.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.