Description

Tyrphostin A25 is a potent and selective inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR). This compound is a critical research tool for studying signal transduction pathways involved in cell proliferation, differentiation, and oncogenesis. It is primarily utilized by researchers and scientists in the fields of biochemistry, oncology, and pharmacology for in vitro and in vivo studies.

Application

• Biochemical Research: Used as a selective EGFR tyrosine kinase inhibitor to study receptor-mediated signaling cascades.
• Oncology Studies: Investigated for its potential anti-proliferative effects on various cancer cell lines, including breast, lung, and colon cancers.
• Signal Transduction Analysis: A key reagent for dissecting the role of tyrosine phosphorylation in cellular processes.
• Drug Discovery: Serves as a lead compound or reference standard in the development of novel targeted cancer therapeutics.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical studies in university and industrial laboratories.

Basic Information

Product Name	Tyrphostin A25
CAS No.	118409-58-8
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 82; RG 50810; Tyrphostin AG 82; 3,4-Dihydroxy-α-cyanocinnamomitrile; α-Cyano-3,4-dihydroxycinnamamide; (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; EGFR Tyrosine Kinase Inhibitor AG82; NSC 654705
EINECS	Contact for details

Quality Control

Our Tyrphostin A25 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided to ensure it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.