Description

Jak2 Inhibitor Iii, Sd-1029 is a potent and selective small molecule inhibitor targeting the Janus kinase 2 (JAK2) signaling pathway. This compound is a critical research tool for investigating cellular signaling mechanisms related to proliferation, hematopoiesis, and immune response. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in oncology, immunology, and inflammatory disease research.

Application

• Biochemical Research: Used as a selective inhibitor to study JAK-STAT signaling pathways in cell-based assays.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the development of novel JAK2-targeted therapeutics.
• Oncology Research: Investigated for its effects on cancer cell lines, particularly those driven by JAK2 mutations (e.g., myeloproliferative neoplasms).
• Immunology Studies: Applied in research exploring the role of JAK2 in immune cell function and autoimmune disease models.
• Pharmacology Profiling: Employed in vitro and in vivo to assess potency, selectivity, and pharmacokinetic properties.
• Academic Research: A key reagent for fundamental studies in signal transduction and cellular communication.

Basic Information

Item	Detail
Product Name	Jak2 Inhibitor Iii, Sd-1029
CAS No.	118372-34-2
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	SD-1029; JAK2 Inhibitor III; AG 490; Tyrphostin AG 490; Tyrphostin B42; NSC 75975; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; α-Cyano-3,4-dihydroxy-N-benzylcinnamamide
EINECS	Contact for details

Quality Control

Our Jak2 Inhibitor Iii, Sd-1029 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (NMR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.