Description

Brl 44408 Maleate is a selective α1A-adrenoceptor antagonist of significant interest in pharmacological research. This compound serves as a critical tool for investigating receptor subtype specificity and function in various physiological systems. It is primarily utilized by researchers and developers in the pharmaceutical and life sciences industries for preclinical studies and drug discovery programs targeting urogenital disorders, cardiovascular function, and neurological pathways.

Application

• Pharmacological Research: A key reference standard and active agent for studying α1-adrenoceptor subtypes, particularly the α1A receptor.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for novel therapeutics targeting benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).
• Biochemical Assays: Employed in receptor binding studies, functional assays (e.g., calcium mobilization), and enzyme inhibition tests to elucidate signal transduction mechanisms.
• Academic & Institutional Research: Supports fundamental neuroscience and cardiovascular research exploring autonomic nervous system regulation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Brl 44408 Maleate
CAS No.	118343-19-4
Molecular Formula	C20H24N2O5
Molecular Weight	372.42 g/mol
Synonyms	BRL-44408; BRL 44408; BRL44408; 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate; (R)-2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole (Z)-2-butenedioate; α1A-Adrenoceptor Antagonist BRL 44408
EINECS	Contact for details

Quality Control

Our Brl 44408 Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets high-grade research standards. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.