Description

Duocarmycin A is a potent, naturally occurring antitumor antibiotic belonging to the cyclopropapyrroloindole (CPI) family. Its unique molecular structure enables it to bind covalently to the minor groove of DNA, making it a compound of significant interest in oncology research and drug discovery. This high-purity compound is essential for pharmaceutical R&D, particularly for scientists developing novel antibody-drug conjugates (ADCs) and studying DNA alkylation mechanisms.

Application

• Antibody-Drug Conjugate (ADC) Payload Development: Serves as a highly potent warhead in the design and synthesis of next-generation targeted cancer therapies.
• Oncology Research: Used as a reference standard and active agent in in vitro and in vivo studies to investigate cytotoxicity and antitumor activity.
• Mechanistic Studies: A critical tool for biochemical research into DNA minor groove alkylation and sequence-selective binding.
• Pharmaceutical Intermediate: Acts as a key building block for the synthetic preparation of duocarmycin analogs and derivatives with tailored properties.
• Bioconjugation Chemistry: Employed in the development of linker-payload systems for targeted delivery platforms.
• Cell Biology & Pharmacology: Used to study cellular apoptosis pathways and the effects of potent DNA-damaging agents.

Basic Information

Product Name	Duocarmycin A
CAS No.	118292-34-5
Molecular Formula	C₃₄H₄₀N₄O₈
Molecular Weight	632.70 g/mol
Synonyms	Duocarmycin A; (1S,8S,20S,21S,22R)-22-[(2S)-2-[(2S,3R,4S,5S)-5-[(1S)-1-Hydroxyethyl]-3,4-dimethyloxolan-2-yl]pyrrolidin-1-yl]-8,21-dimethyl-17-oxa-2,11,24-triazapentacyclo[19.3.1.1³,⁸.1¹⁰,¹⁴.0⁴,⁹]hexacosa-4,6,9,11,13,25-hexaene-5,16,23-trione; CC-1065 analog; CPI-based DNA alkylator
EINECS	Contact for details

Quality Control

Our Duocarmycin A is manufactured under strict quality management systems to ensure the highest standards of purity and consistency for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided, documenting critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Store in a dedicated, secure facility for potent active pharmaceutical ingredients (APIs).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.