Description

Af-Dx 384 CAS NO 118290-27-0 is a specialized chemical compound used as a high-affinity muscarinic receptor antagonist in advanced research. This compound is critical for investigating cholinergic systems and receptor pharmacology, providing valuable insights for neurological and therapeutic studies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neuroscience and drug discovery.

Application

• Neuroscience Research: A key tool for studying muscarinic acetylcholine receptor subtypes (M1, M2, M3, M4) in the central and peripheral nervous systems.
• Pharmacological Profiling: Used in competitive binding assays and functional studies to characterize receptor-ligand interactions and signal transduction pathways.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in the screening and development of new therapeutic agents targeting cholinergic disorders.
• Biochemical Assays: Employed in vitro to determine receptor density, affinity (Ki, IC50 values), and antagonist potency in tissue preparations and cell cultures.
• Academic & Clinical Research: Supports fundamental research into conditions such as Alzheimer's disease, Parkinson's disease, chronic obstructive pulmonary disease (COPD), and smooth muscle dysfunction.

Basic Information

Product Name	Af-Dx 384
CAS No.	118290-27-0
Molecular Formula	C23H26N2O4
Molecular Weight	394.47 g/mol
Synonyms	AF-DX 384; AFDX 384; AFDX-384; 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one; Pirenzepine Diethylamino Analog; Muscarinic M2 Receptor Antagonist AF-DX 384
EINECS	Contact for details

Quality Control

Every batch of Af-Dx 384 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for parameters including assay purity, identification, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.