Description

7-o-Ethyl Fangchinoline is a semi-synthetic derivative of the natural bisbenzylisoquinoline alkaloid fangchinoline, characterized by the ethylation at the 7-oxygen position. This structural modification is of significant interest for enhancing specific biological activities and altering physicochemical properties for research and development purposes. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for pharmacological studies, as a reference standard, and as a key intermediate in synthetic chemistry.

Application

• Pharmacological Research: Used as a reference compound and active pharmaceutical ingredient (API) intermediate in studies targeting calcium channel modulation, anti-inflammatory, and anti-tumor activities.
• Biochemical Assay Development: Serves as a critical standard for developing and validating analytical methods (e.g., HPLC, LC-MS) for alkaloid quantification and purity assessment.
• Medicinal Chemistry: Acts as a versatile synthetic building block for creating novel analogs to explore structure-activity relationships (SAR) and improve drug-like properties.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research on natural product derivatives and their mechanisms of action.
• Quality Control & Standardization: Essential as a high-purity certified reference material (CRM) for ensuring the quality and consistency of herbal extracts and related products.

Basic Information

Product Name	7-o-Ethyl Fangchinoline
CAS No.	118160-59-1
Molecular Formula	C39H44N2O6
Molecular Weight	636.78 g/mol
Synonyms	7-O-Ethylfangchinoline; Ethyl Fangchinoline; 7-Ethoxyfangchinoline; 2-Methyl-6,7-dimethoxy-1-[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]-3-ethyl-3,4-dihydroisoquinolin-2-ium; Fangchinoline 7-O-ethyl ether; (1R)-1-[(6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]-6,7-dimethoxy-2-methyl-3-ethyl-3,4-dihydroisoquinolin-2-ium
EINECS	Contact for details

Quality Control

Our 7-o-Ethyl Fangchinoline is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Quality assurance protocols include identity confirmation by spectroscopic methods and purity determination by chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each batch to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.