Description

Para-Chlorofentanyl (Hydrochloride) is a high-purity synthetic opioid derivative, specifically the hydrochloride salt of para-chlorofentanyl. This compound is of significant interest in advanced pharmacological research and analytical chemistry, serving as a critical reference standard and a key intermediate in specialized synthetic pathways. It is primarily utilized by research institutions, forensic laboratories, and pharmaceutical development companies engaged in receptor studies, metabolic profiling, and the synthesis of novel chemical entities for investigative purposes.

Application

• Pharmacological Research: Acts as a potent reference standard for studying opioid receptor binding affinity, selectivity, and signal transduction mechanisms.
• Forensic Analysis: Used as a certified reference material (CRM) for the accurate identification and quantification of novel synthetic opioids in forensic toxicology and law enforcement laboratories.
• Metabolic Studies: Employed in in vitro and in vivo studies to investigate the metabolic pathways, pharmacokinetics, and biotransformation products of fentanyl analogs.
• Chemical Synthesis: Serves as a crucial synthetic intermediate or precursor in the development of novel chemical compounds for investigative and research applications.
• Analytical Method Development: Essential for developing, validating, and calibrating highly sensitive analytical methods such as LC-MS/MS, GC-MS, and HPLC in analytical laboratories.
• Biomedical Research: Utilized in controlled research settings to explore the structure-activity relationships (SAR) of synthetic opioids and their physiological effects.

Basic Information

Product Name	Para-Chlorofentanyl (Hydrochloride)
CAS No.	117994-27-1
Molecular Formula	C22H28ClN2O • HCl
Molecular Weight	417.84 g/mol (for hydrochloride salt)
Synonyms	4'-Chlorofentanyl Hydrochloride; N-Phenethyl-4-chloro-N-(1-phenethylpiperidin-4-yl)propionamide Hydrochloride; Para-Chlorofentanyl HCl; 4-Chlorofentanyl Hydrochloride; 1-Phenethyl-4-(N-phenylpropionamido)piperidine, 4'-chloro-, hydrochloride; Fentanyl, 4'-chloro-, hydrochloride
EINECS	Contact for details

Quality Control

Our Para-Chlorofentanyl (Hydrochloride) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity assay by HPLC, and stringent control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.