Description

Maytansine, 2-De(Acetylmethylamino)-15-Methoxy-2-Methyl- is a highly potent ansamycin-class cytotoxin that serves as a critical payload in the development of antibody-drug conjugates (ADCs). Its core value lies in its ability to selectively target and destroy cancer cells when linked to tumor-specific monoclonal antibodies, offering a powerful therapeutic strategy with reduced systemic toxicity. This compound is essential for pharmaceutical R&D teams, biotech companies, and contract research organizations (CROs) focused on advancing next-generation oncology treatments.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as the cytotoxic warhead in targeted cancer therapies.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies of novel ADC constructs.
• Bioconjugation Chemistry: Serves as a key intermediate for researchers developing new linker-payload technologies to optimize ADC stability and potency.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and the mechanism of action of maytansinoids.
• Process Development: Used in the scale-up and optimization of ADC manufacturing processes within GMP environments.

Basic Information

Product Name	Maytansine, 2-De(Acetylmethylamino)-15-Methoxy-2-Methyl-
CAS No.	117860-08-9
Molecular Formula	C35H48ClN3O9
Molecular Weight	690.22 g/mol
Synonyms	DM1; Mertansine; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; Maytansinoid DM1; 2-Mercapto-N-(2-deacetyl-2-(methylamino)-15-methoxy-5,9-dimethyl-14-oxo-4,13-dioxa-3,8,12-triazapentadeca-1,6,10-trien-15-yl)acetamide; (3S,4R,5S,6R)-6-[(1R,2R,3S,4S,6R)-4-[(2S,3S)-3-[(2R)-1-Hydroxypropan-2-yl]oxiran-2-yl]-2,6-dimethyl-3-(methylamino)oxan-2-yl]oxy-4-methoxy-5-methyl-3-prop-1-en-2-yloxan-2-yl N-methyl-N-[(1S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]oxypropan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Maytansine, 2-De(Acetylmethylamino)-15-Methoxy-2-Methyl- (DM1) is produced under strict quality management systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.