Description

5-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzaldehyde is a versatile and high-value fluorinated aromatic aldehyde building block. This compound is critical for the synthesis of advanced agrochemicals and pharmaceuticals, where its unique halogen and trifluoromethyl substitution pattern imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and trifluoromethyl groups for enhanced efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and other electronic materials due to its electron-withdrawing properties.
• Cross-Coupling Reactions: The aldehyde and halogen functionalities make it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to build complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up manufacturing for clients requiring specific fluorinated benzaldehyde derivatives.

Basic Information

Product Name	5-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzaldehyde
CAS No.	117752-05-3
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	5-Chloro-2-fluoro-3-(trifluoromethyl)benzaldehyde; 3-Trifluoromethyl-5-chloro-2-fluorobenzaldehyde; 2-Fluoro-5-chloro-α,α,α-trifluoro-m-tolualdehyde; Benzaldehyde, 5-chloro-2-fluoro-3-(trifluoromethyl)-; 117752-05-3; 5-Chloro-2-fluoro-alpha,alpha,α-trifluoro-m-tolualdehyde
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Fluoro-3-(Trifluoromethyl)Benzaldehyde is produced under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.