Description

Methyl 2,6-Difluoronicotinate is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for introducing the difluoronicotinate moiety into complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of modern pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialized ligands for catalysis and functional materials.
• Chemical Research: A valuable reagent for academic and industrial R&D focused on fluorinated heterocyclic chemistry and structure-activity relationship (SAR) studies.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	Methyl 2,6-Difluoronicotinate
CAS No.	117671-02-0
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2,6-Difluoronicotinic Acid Methyl Ester; Methyl 2,6-Difluoropyridine-3-carboxylate; 3-Carbomethoxy-2,6-difluoropyridine; 2,6-Difluoro-3-pyridinecarboxylic Acid Methyl Ester; Methyl 2,6-Difluoro-3-pyridinecarboxylate; 117671-02-0; 2,6-Difluoronicotinic acid, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2,6-Difluoronicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed and stored in a desiccator if long-term storage is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.