Description

Calpeptin is a potent, cell-permeable calpain inhibitor widely used in biochemical and pharmacological research. This compound is critical for studying the role of calpain proteases in cellular processes such as apoptosis, signal transduction, and cytoskeletal remodeling. It is an essential research tool for scientists in the fields of neuroscience, cardiology, and cell biology, enabling the investigation of disease mechanisms related to calpain overactivity.

Application

• Biomedical Research: Fundamental tool for inhibiting calpain activity in cell culture and in vitro enzymatic assays to study its physiological and pathological roles.
• Neuroscience Studies: Used to investigate calpain-mediated processes in neuronal cell death, synaptic plasticity, and neurodegenerative conditions like Alzheimer's and Parkinson's disease.
• Cardiovascular Research: Applied in models of ischemia-reperfusion injury, myocardial infarction, and heart failure to elucidate the involvement of calpain in cardiac cell damage.
• Muscle Biology: Employed to study calpain's function in muscle protein turnover, atrophy, and muscular dystrophy research.
• Apoptosis & Cell Signaling Pathways: Essential for dissecting the complex signaling cascades where calpain acts as a key regulatory protease.
• Pharmaceutical Development: Serves as a reference compound and pharmacological probe in the discovery and validation of novel calpain inhibitors for therapeutic applications.

Basic Information

Product Name	Calpeptin
CAS No.	117591-20-5
Molecular Formula	C₂₀H₃₀N₄O₄
Molecular Weight	390.48 g/mol
Synonyms	Z-Leu-Nle-CHO; Benzyloxycarbonyl-Leucyl-Norleucinal; Calpain Inhibitor I; N-Benzyloxycarbonyl-L-leucyl-L-norleucinal; Z-Leu-Nle-al; MDL 28170; (2S)-2-[[(2S)-1-[[(2S)-1-[(Benzyloxy)amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methylpentanal
EINECS	Contact for details

Quality Control

Our Calpeptin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.