Description

Paclitaxel Succinate CAS NO 117527-50-1 is a semi-synthetic, water-soluble prodrug derivative of the potent anticancer agent Paclitaxel. This compound is engineered to enhance solubility and improve drug delivery profiles, addressing a key challenge in oncology formulation. It is primarily utilized by pharmaceutical R&D teams and manufacturers in the development of next-generation chemotherapeutic injectables and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Critical starting material for synthesizing advanced, more soluble Paclitaxel prodrugs and conjugates.
• Oncology Drug Development: Used in research and formulation of novel chemotherapeutic agents targeting various solid tumors.
• Drug Delivery Systems: Key component in the development of nanoparticle carriers, liposomes, and polymer-drug conjugates to improve bioavailability and reduce side effects.
• Preclinical & Clinical Research: Serves as a reference standard and active ingredient in pharmacokinetic, pharmacodynamic, and efficacy studies.
• Solubility Enhancement: Employed to create derivatives with improved aqueous solubility over native Paclitaxel for better intravenous formulation.
• Targeted Therapy Conjugates: Used to create antibody-drug conjugates (ADCs) or ligand-targeted prodrugs for specific cancer cell targeting.

Basic Information

Product Name	Paclitaxel Succinate
CAS No.	117527-50-1
Molecular Formula	C₅₀H₅₅NO₁₆
Molecular Weight	926.0 g/mol
Synonyms	Paclitaxel 2'-Succinate; 2'-Succinylpaclitaxel; Paclitaxel Succinate Ester; Taxol Succinate; 7-Epi-paclitaxel 2'-succinate?; NSC 758855; Succinic acid paclitaxel ester; β-Paclitaxel succinate
EINECS	Contact for details

Quality Control

Our Paclitaxel Succinate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed for pharmaceutical R&D use. We support audits and can provide regulatory starting material documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.