Description

3,5-Difluorotoluene is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the toluene ring, which significantly influences the electronic properties and metabolic stability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where fluorine substitution can improve environmental stability and efficacy.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for advanced display technologies.
• Organic Electronics: Employed in the development of novel organic semiconductors and electronic materials due to its ability to fine-tune electronic properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for constructing complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.

Basic Information

Item	Details
Product Name	3,5-Difluorotoluene
CAS No.	117358-51-7
Molecular Formula	C7H6F2
Molecular Weight	128.12 g/mol
Synonyms	1,3-Difluoro-5-methylbenzene; 3,5-Difluoro-1-methylbenzene; 5-Methyl-1,3-difluorobenzene; α,α,α,3,5-Pentafluorotoluene (incorrect but common misnomer to clarify); Difluorotoluene (mixed isomer); Toluene, 3,5-difluoro-; Benzene, 1,3-difluoro-5-methyl-
EINECS	Contact for details

Quality Control

Our 3,5-Difluorotoluene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent evaporation and moisture absorption.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Density (at 20°C)	~1.15 g/cm³
Boiling Point	~142-144 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.