Description

2-Hydroxysaclofen is a potent and selective antagonist for GABAB receptors, serving as a key research tool in neuropharmacology. Its primary value lies in its ability to help scientists elucidate the complex roles of GABAB receptor signaling in the central nervous system. This compound is essential for researchers and developers in the pharmaceutical and life sciences industries, particularly those focused on neurological disorders, pain management, and receptor characterization studies.

Application

• Neuroscience Research: A critical tool for studying GABAB receptor function, localization, and downstream signaling pathways in vitro and in vivo.
• Pharmacological Profiling: Used in high-throughput screening (HTS) and assay development to identify and characterize novel GABAB receptor modulators.
• Disease Model Studies: Applied in preclinical research models for conditions such as epilepsy, spasticity, anxiety, and chronic pain to understand receptor involvement.
• Biochemical Research: Employed in receptor binding assays and studies of neurotransmitter release inhibition mediated by GABAB receptors.
• Academic & Institutional R&D: Fundamental for university laboratories and research institutes conducting basic neurobiological research.
• Pharmaceutical Development: Supports early-stage drug discovery programs targeting the GABAergic system for therapeutic intervention.

Basic Information

Product Name	2-Hydroxysaclofen
CAS No.	117354-64-0
Molecular Formula	C10H12ClNO4S
Molecular Weight	277.72 g/mol
Synonyms	2-Hydroxy Saclofen; (3-Amino-2-(4-chlorophenyl)-2-hydroxypropyl)sulfonic acid; 2-Hydroxy-3-(4-chlorophenyl)-3-[(sulfooxy)amino]propane; GABAB receptor antagonist; Saclofen derivative; 4-Chloro-3-hydroxy-3-(sulfomethyl)phenylalanine derivative
EINECS	Contact for details

Quality Control

Our 2-Hydroxysaclofen is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.