Description

2,6-Difluorocinnamaldehyde is a versatile fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms on the aromatic ring, which profoundly influences the electronic properties and metabolic stability of final compounds. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients. Its unique structure enables the synthesis of complex molecules with tailored biological and physical properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies, where the difluoro motif enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging fluorine's ability to improve lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic semiconductors and liquid crystal compounds, contributing to improved charge transport and display performance.
• Advanced Polymer Chemistry: Employed in the synthesis of specialty polymers and coatings, where the fluorine atoms can impart unique chemical resistance, low surface energy, and thermal stability.
• Fluorescent Probe & Dye Development: Acts as a starting material for creating fluorophores and molecular probes used in bio-imaging and diagnostic applications.
• Cross-Coupling Reactions: The aldehyde and halogen functionalities make it a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.

Basic Information

Item	Detail
Product Name	2,6-Difluorocinnamaldehyde
CAS No.	117338-43-9
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	2,6-Difluorocinnamaldehyde; (E)-3-(2,6-Difluorophenyl)prop-2-enal; 2,6-Difluoro-trans-cinnamaldehyde; 3-(2,6-Difluorophenyl)-2-propenal; α-(2,6-Difluorophenyl)acrolein; Cinnamaldehyde, 2,6-difluoro-; 2,6-Difluorobenzeneacrolein
EINECS	Contact for details

Quality Control

Our 2,6-Difluorocinnamaldehyde is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity determination, GC for residual solvent analysis, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the container to reach ambient temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.