Description

Etoposide Phosphate is a highly water-soluble prodrug of the potent topoisomerase II inhibitor, etoposide. This enhanced solubility profile is critical for formulating stable and bioavailable injectable pharmaceutical products. It is an essential active pharmaceutical ingredient (API) and key intermediate for manufacturers in the oncology sector. The compound is primarily utilized in the research, development, and production of chemotherapeutic agents targeting various cancers.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable chemotherapy formulations.
• Oncological Research: A critical compound for in-vitro and in-vivo studies on cancer cell apoptosis and topoisomerase II inhibition.
• Drug Development: Serves as a key intermediate in the synthesis and development of novel anti-cancer therapeutics and combination therapies.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and other pharmacopeial methods.
• Preclinical Studies: Employed in pharmacokinetic and pharmacodynamic modeling due to its improved solubility over etoposide.

Basic Information

Product Name	Etoposide Phosphate
CAS No.	117091-64-2
Molecular Formula	C29H33O16P
Molecular Weight	668.54 g/mol
Synonyms	Etoposide 4'-Phosphate; Etoposide Diphosphate; BMY-40481; Vepesid Phosphate; (5S,5aR,8aR,9R)-9-(((4aR,6R,7R,8S,8aS)-6,7,8,8a-Tetrahydro-4H,6H-7,8a-methano[1,3]dioxolo[4,5-g]isoquinolin-6-yl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one 4'-(dihydrogen phosphate); NSC 354719
EINECS	Contact for details

Quality Control

Our Etoposide Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and other relevant pharmacopeial methods. We support compliance with cGMP, ICH Q7, and other relevant regulatory guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.