Description

Combretastatin A5 is a potent synthetic stilbenoid compound that serves as a key pharmaceutical intermediate and research chemical. Its primary value lies in its role as a structural analog in the development of novel tubulin polymerization inhibitors for oncology research. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers focused on developing next-generation vascular disrupting agents and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Critical starting material or building block in the synthesis of advanced investigational new drugs (INDs) targeting cancer.
• Oncology Research: Used as a reference standard and active compound in in vitro and in vivo studies to evaluate anti-angiogenic and vascular disrupting activity.
• Mechanistic Studies: Employed in biochemical assays to study the inhibition of tubulin polymerization and its effects on cytoskeleton dynamics.
• Structure-Activity Relationship (SAR) Research: Serves as a core scaffold for medicinal chemists to design and synthesize novel analogs with optimized potency and pharmacokinetic profiles.
• Preclinical Development: Supplied for formulation studies and toxicology assessments required in the drug discovery pipeline.

Basic Information

Product Name	Combretastatin A5
CAS No.	117048-60-9
Molecular Formula	C18H20O5
Molecular Weight	316.35 g/mol
Synonyms	(Z)-3,4,5-Trimethoxy-3',4'-methylenedioxystilbene; CA5; Combretastatin A-5; 1,2-(Methylenedioxy)-4-(3,4,5-trimethoxystyryl)benzene; 5-[(1Z)-2-(3,4-Methylenedioxyphenyl)ethenyl]-1,2,3-trimethoxybenzene
EINECS	Contact for details

Quality Control

Our Combretastatin A5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP intermediate requirements. Specifications are designed to meet the stringent needs of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.