Description

Combretastatin A-4 is a potent, naturally occurring stilbenoid compound originally isolated from the African bush willow, *Combretum caffrum*. It serves as a critical pharmacological reference standard and a key structural template in oncology research due to its function as a vascular disrupting agent (VDA). This high-purity compound is essential for researchers and developers in pharmaceutical R&D, particularly those focused on anti-cancer drug discovery and the synthesis of novel tubulin-binding agents. Its consistent quality and stability are paramount for ensuring reliable experimental and pre-clinical results.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quality control and validation of analytical methods (e.g., HPLC, LC-MS) in drug development.
• Anti-Cancer Research: Serves as a lead compound and molecular probe in studies targeting tumor vasculature, angiogenesis, and metastasis.
• Medicinal Chemistry & SAR Studies: Provides the core structure for the design, synthesis, and structure-activity relationship (SAR) analysis of novel tubulin polymerization inhibitors.
• Biochemical Assays: Utilized in *in vitro* and cell-based assays to study mechanisms of action involving cytoskeleton disruption and endothelial cell apoptosis.
• Pre-clinical Development: Acts as a benchmark for evaluating the efficacy and pharmacokinetics of next-generation vascular disrupting agents in animal models.

Basic Information

Product Name	Combretastatin A-4
CAS No.	117048-59-6
Molecular Formula	C18H20O5
Molecular Weight	316.35 g/mol
Synonyms	Combretastatin A4; (Z)-1-(3,4,5-Trimethoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethene; CA-4; NSC 64087; Phenstatin analogue; Stilbenoid CA4; Vascular Disrupting Agent CA4
EINECS	Contact for details

Quality Control

Our Combretastatin A-4 is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for analytical reference materials, ensuring data integrity and traceability for critical pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.